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Utility of serum periostin and free I g E levels in evaluating responsiveness to omalizumab in patients with severe asthma
Author(s) -
Tajiri T.,
Matsumoto H.,
Gon Y.,
Ito R.,
Hashimoto S.,
Izuhara K.,
Suzukawa M.,
Ohta K.,
Ono J.,
Ohta S.,
Ito I.,
Oguma T.,
Inoue H.,
Iwata T.,
Kanemitsu Y.,
Nagasaki T.,
Niimi A.,
Mishima M.
Publication year - 2016
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12922
Subject(s) - periostin , omalizumab , medicine , exacerbation , asthma , eosinophil , biomarker , immunology , gastroenterology , antibody , immunoglobulin e , biochemistry , chemistry , extracellular matrix , biology , microbiology and biotechnology
Background Omalizumab, a humanized anti‐ I g E monoclonal antibody, has demonstrated efficacy in patients with severe allergic asthma. However, treatment responses vary widely among individuals. Despite a lack of data, free serum I g E levels following omalizumab treatment have been proposed as a marker of treatment responsiveness. Methods In this prospective, observational study, we assessed the utility of biomarkers of type 2 inflammation in predicting omalizumab treatment responses, as determined by the absence of asthma exacerbation during the first year of treatment. Free serum I g E levels were monitored for 2 years to examine their association with baseline biomarker levels and the number of exacerbations. Results We enrolled thirty patients who had been treated with omalizumab for at least 1 year, of whom 27 were treated for 2 years. Baseline serum periostin levels and blood eosinophil counts were significantly higher in patients without exacerbations during the first year of treatment than in patients with exacerbations. Baseline serum periostin levels, but not eosinophil counts, were negatively associated with free serum I g E levels after 16 or 32 weeks of treatment. Reduced free serum I g E levels during treatment from those at baseline were associated with reduced exacerbation numbers at 2 years. In 14 patients who continued to have exacerbations during the first year of treatment, exacerbation numbers gradually and significantly decreased over the 2‐year study period, with concurrent significant reductions in free serum I g E levels. Conclusion Baseline serum periostin levels and serum free I g E levels during treatment follow‐up may be useful in evaluating responses to omalizumab treatment.