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Clinical relevance of molecular diagnosis in pet allergy
Author(s) -
Uriarte S. A.,
Sastre J.
Publication year - 2016
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12917
Subject(s) - medicine , immunoglobulin e , asthma , allergy , respiratory allergy , clinical significance , respiratory system , immunology , dermatology , allergen , antibody
Abstract We describe the pattern of sensitisation to pet IgE components and its association with clinical symptoms. Hundred and fifty nine consecutive patients with rhinitis/asthma sensitised to dog, cat, and horse were recruited. Specific IgE to whole extracts and to pet recombinant allergens were performed. Only 5% of patients were monosensitised to animal allergens. Specific IgE to Can f 1 was significantly associated with persistent rhinitis, Can f 2 with asthma diagnosis, Can f 3 with moderate/severe rhinitis (M/S‐R) and asthma diagnosis (AD), and Can f 5 with persistent and M/S‐R. Positive IgE to Fel d 2 was significantly associated with M/S‐R and AD, Equ c 1 with M/S‐R and Equ c 3 with persistent rhinitis, AD and severe asthma. Sensitisation to ≥2 molecules or to pet albumins was associated with more severe respiratory symptoms. Molecular diagnosis in patients with pet allergy may also help clinicians to predict clinical symptoms and their severity.