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Childhood atopic dermatitis—Brain‐derived neurotrophic factor correlates with serum eosinophil cationic protein and disease severity
Author(s) -
FölsterHolst R.,
Papakonstantinou E.,
Rüdrich U.,
Buchner M.,
Pite H.,
Gehring M.,
Kapp A.,
Weidinger S.,
Raap U.
Publication year - 2016
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12916
Subject(s) - eosinophil cationic protein , brain derived neurotrophic factor , scorad , medicine , atopic dermatitis , immunology , eosinophil , neurotrophic factors , immunoglobulin e , pathophysiology , disease , receptor , antibody , asthma , dermatology life quality index
Several studies have shown that neurotrophins including brain‐derived neurotrophic factor ( BDNF ) play a role in chronic inflammatory skin diseases such as atopic dermatitis ( AD ). BDNF is increased in the serum samples of adults with AD . Interestingly, eosinophils of these patients can release and produce BDNF . We analyzed BDNF serum levels with ELISA and their correlation with SCORAD score, eosinophil cationic protein ( ECP ), total IgE, IL ‐4, IL ‐13 and IL ‐31 in children with AD ( n = 56) compared to nonatopic healthy children ( n = 25). In addition, we analyzed FLG loss‐of‐function mutations in 17 children with AD and their connection to BDNF . BDNF serum levels were significantly higher in children with AD . Further, BDNF correlated with disease activity, serum ECP , and total IgE serum levels in AD . There was no difference in BDNF levels of filaggrin‐positive or filaggrin‐negative children with AD , and there was no correlation of BDNF with IL ‐31 and Th2 cytokines including IL ‐4 and IL ‐13. Together, our data add new insights into the pathophysiology of AD , suggesting that serum BDNF which correlates with disease severity contributes to the regulation of inflammation in an eosinophil‐, but not Th2‐dependent manner.