Late Breaking Poster Session Group II – Red LB TPS 13

[[abstract]]Background: Although there is evidence that exposure to environmental tobacco smoke (ETS) is harmful to children 0 s respiratory health, but the effect of ETS on the regulation of IgE-mediated immune responses to specic allergens remain unclear. This study aimed to investigate the relationship between ETS exposure and specic immunoglobulin E (IgE) prole for a broad spectrum of allergens in a population setting. Method: Children aged 5 – 18 years ( n = 1315) were assessed using serum cotinine measurement and microarray-based multiplexed detection of specic IgE against 40 allergens. Results: Serum cotinine levels were signicantly positively associated with sensitization to cockroaches ( P = 0.005), pollen ( P = 0.02), and foods ( P = 0.006), respectively. Specically, higher serum cotinine levels were signicantly related to sensitization to the following specic allergens: Oriental cockroach, Timothy grass, Bermuda grass, cow 0 s milk, egg white, crab, shrimp, soybean, potato, peanut, almond, garlic, and cheese (all P < 0.05). When considering the degree of allergic sensitization, serum cotinine levels were signicantly and positively correlated to the number of sensitization to cockroaches ( P = 0.004), pollen ( P = 0.006), and foods ( P < 0.001), respectively. Similar results were observed when summing up specic IgE concentrations for the aforementioned allergen categories. Meanwhile, signicant positive associations were found between serum cotinine levels and rhinitis ever (AOR = 2.95; 95% CI: 1.15 – 7.60) and cur rent rhinitis (AOR = 2.71; 95% CI: 1.07 – 6.89). Conclusion: The association between ETS exposure and sensitization to environmental allergens varies for different allergens among children. This study demonstrates that elevated serum cotinine levels are signicantly associated with IgE sensitization to cockroaches, grass pollen, and certain foods, respectively, with possible dose-dependent effects