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Comparable profiles of serum histamine and IgG4 levels in allergic beekeepers
Author(s) -
Chliva C.,
Aggelides X.,
Makris M.,
Katoulis A.,
Rigopoulos D.,
Tiligada E.
Publication year - 2015
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12568
Subject(s) - histamine , immunoglobulin e , immunology , allergen , allergy , medicine , antibody , allergic response
Growing evidence identifies histamine as a key player in allergic responses, but the reports relating serum histamine to tolerance are scarce and inconclusive. This study investigated the relationship of circulating histamine to the tolerant phenotype in allergic beekeepers. The results showed a positive correlation between the serum levels of histamine and specific immunoglobulin G4 ( sIgG 4) to honeybee venom, but not with total IgE or sIgE . Interestingly, both sIgG 4 and histamine levels were negatively correlated with the time since the last bee sting. In contrast to total IgE and sIgE , serum sIgG 4 and histamine levels followed comparable patterns, being higher in tolerant/recently stung individuals and lower in the least frequently stung subgroup. The data obtained in this pilot study associated, for the first time, serum histamine levels with allergen tolerance in allergic individuals and provided the lead for further considering the putative immunomodulatory properties of histamine in allergic responses.