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Anaphylactic bronchospasm during general anesthesia is not related to asthma
Author(s) -
GouelChéron A.,
Neukirch C.,
Aubier B.,
Montravers P.,
Nicaise P.,
CholletMartin S.,
Mertes P.M.,
Aubier M.,
Longrois D.
Publication year - 2015
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12565
Subject(s) - bronchospasm , medicine , asthma , anesthesia , immunoglobulin e , anaphylaxis , logistic regression , anaphylactic shock , risk factor , population , allergy , immunology , environmental health , antibody
In the general population, a history of asthma ( HA ) is associated with a higher risk of mortality of anaphylactic shock ( AS ), but it is unknown whether this association remains valid for intra‐operative AS . The goal of this retrospective study was to investigate whether a HA was associated with a higher risk of bronchospasm during intra‐operative AS . We analyzed 106 patients (January 2009–December 2012) with intra‐operative AS : 57% of them had a confirmed IgE‐mediated reaction and 27% had a HA . On logistic regression, the only factor statistically associated with bronchospasm was a neuromuscular blocking drug, with both IgE‐ or non‐IgE‐mediated reactions. These results suggest that the mechanisms of bronchospasm in AS may be different from those of asthma and that, in the presence of bronchospasm during anesthesia, AS should be considered to be the most likely cause.