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Natural evolution of skin‐test sensitivity in patients with IgE‐mediated hypersensitivity to cephalosporins
Author(s) -
Romano A.,
Gaeta F.,
Valluzzi R. L.,
Zaffiro A.,
Caruso C.,
Quaratino D.
Publication year - 2014
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12390
Subject(s) - cephalosporin , medicine , immunoglobulin e , skin test , allergy , immunology , dermatology , group a , group b , radioallergosorbent test , antibiotics , allergen , pathology , antibody , microbiology and biotechnology , biology , tuberculosis
There are studies demonstrating that skin‐test sensitivity to penicillins can decrease over time and that allergic patients may lose sensitivity if the responsible compounds are avoided. With regard to subjects with I gE‐mediated hypersensitivity to cephalosporins, however, such studies are lacking. We evaluated prospectively in a 5‐year follow‐up 72 cephalosporin‐allergic patients. After the first evaluation, patients were classified into two groups according to their patterns of allergologic‐test positivity: to both penicillins and cephalosporins (group A), or only to cephalosporins (group B). Skin tests and serum‐specific IgE assays were repeated 1 year later and, in case of persistent positivity, 3 and 5 years after the first allergologic examination. Seven (43.7%) of the 16 subjects of group A and 38 (67.8%) of the 56 patients of group B became negative; one was lost to follow‐up. Patients of group B became negative sooner and more frequently than group A subjects.