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Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in a population sample of children
Author(s) -
Yao T.C.,
Tsai H.J.,
Tu Y.L.,
Chang S.W.,
Hua M.C.,
Liao S.L.,
Tsai M.H.,
Chiu C.Y.,
Lai S.H.,
Yeh K.W.,
Huang J.L.
Publication year - 2014
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12378
Subject(s) - cockroach , sensitization , exhaled nitric oxide , immunology , immunoglobulin e , population , allergy , shrimp , nitric oxide , allergen , medicine , asthma , antibody , biology , ecology , environmental health , bronchoconstriction
This study investigated the relationship between the specific immunoglobulin E ( I g E ) profile for 40 allergens using a novel microarray technique ( B io IC ) and fraction of exhaled nitric oxide ( F e NO ) in a population sample of 1321 children. Significant positive associations were found between Fe NO and sensitization to mites ( P   <   0.001), animals ( P   =   0.001), cockroaches ( P   <   0.001), and foods ( P   =   0.042), and furthermore, between F e NO and the number of sensitizations (all P   <   0.05) or the sum of specific I g E (all P   ≤   0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher Fe NO : D ermatophagoides pteronyssinus , D ermatophagoides farina , B lomia tropicalis , cat, G erman cockroach, O riental cockroach, codfish, crab, shrimp, and cheese (all P   ≤   0.01). In conclusion, I g E sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated Fe NO levels in a dose‐dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways.

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