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Aeroallergen and food I g E sensitization and local and systemic inflammation in asthma
Author(s) -
Patelis A.,
Janson C.,
Borres M. P.,
Nordvall L.,
Alving K.,
Malinovschi A.
Publication year - 2014
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12345
Subject(s) - sensitization , medicine , immunoglobulin e , immunology , aeroallergen , asthma , exhaled nitric oxide , allergy , eosinophil , allergen , eosinophilia , spirometry , antibody
Background We recently reported an independent association between I g E sensitization to food allergens and increased airway inflammation, assessed by fraction of exhaled nitric oxide (Fe NO ), in a population‐based study ( J Allergy Clin Immunol , 130 , 2012, 397). Similar studies have not been performed in populations with asthma. The aim of the present study was to investigate the allergic sensitization profile in asthmatics and examine F e NO , airway responsiveness and blood eosinophilia in relation to type and degree of I g E sensitization. Method F e NO , airway responsiveness, blood eosinophil count ( B ‐ E os) and I g E sensitization to food allergens and aeroallergens were determined in 408 subjects with asthma, aged 10–34 years. Results Asthmatics had higher prevalence of I g E sensitization against all allergens than controls ( P < 0.001). Mite, pollen, furry animal, mould and food sensitizations were each associated with increased F e NO , airway responsiveness and B ‐ E os in asthmatics. I g E sensitization to mould, furry animals and food allergens was independently related to F e NO (all P < 0.05) after adjustment for age, sex, height, smoking history and medication. I g E sensitization to mould ( P < 0.001) and furry animals ( P = 0.02) was related to airway responsiveness in a similar model. Finally, I g E sensitization to mould ( P = 0.001), furry animals ( P < 0.001) and food allergens ( P < 0.001) was independently related to B ‐ E os. Conclusion Independent effects of I g E sensitization to aeroallergens (furry animals and mould) and food allergens were found on both local and systemic markers of inflammation in asthma. The finding regarding food I g E sensitization is novel, and a clinical implication might be that even food sensitization must be assessed to fully understand inflammation patterns in asthma.