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Development of a brief questionnaire ( ICQ ‐S) to monitor inhaled corticosteroid side‐effects in clinical practice
Author(s) -
Foster J. M.,
Schokker S.,
Sanderman R.,
Postma D. S.,
Molen T.
Publication year - 2014
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12340
Subject(s) - asthma , cronbach's alpha , medicine , psychology , physical therapy , clinical psychology , psychometrics
Background Side‐effect concerns impede adherence with inhaled corticosteroids ( ICS ) and often underlie poor asthma control. We developed a brief version ( ICQ ‐S) of the 57‐item Inhaled Corticosteroids side‐effect Questionnaire ( ICQ ) to facilitate side‐effect monitoring in busy clinics. Methods Part 1: After completion by 482 patients with doctor‐diagnosed asthma, each ICQ item underwent item reduction analysis. Part 2: Patients prescribed ICS for asthma completed the ICQ at baseline ( BL ), ICQ ‐S at day 14 (D14) and day 28 (D28), and 6‐item Asthma Control Questionnaire ( ACQ ) and Mini Asthma Quality of Life Questionnaire (Mini AQLQ ) at BL , D14 and D28. 14‐day test–retest reliability was assessed by intraclass correlation coefficient ( ICC ) between ICQ ‐S scores and internal consistency by Cronbach's alpha (α) coefficient and item‐total correlations of ICQ ‐S. Criterion validity was assessed by correlations (Spearman's rho) between ICQ and ICQ ‐S total score. Patients reported duration and difficulty of ICQ ‐S completion at D28. Results Part 1: The ICQ ‐S consists of fifteen local/systemic ICS side‐effects of similar range to the full ICQ . Part 2: 62 asthma patients (mean ACQ score 0.79 ± SD 0.83) prescribed daily ICS [ BDP ‐equivalent median dose 1000 μg ( IQR : 500, 1000)] participated. ICC between ICQ ‐S scores was 0.90. All item‐total correlations were rho ≥ 0.20. The ICQ ‐S demonstrated criterion validity, for example, ICQ and ICQ ‐S were strongly associated (rho = 0.86). 81% of patients completed the ICQ ‐S within 5 minutes and 97% found completion ‘not difficult’. Conclusion The ICQ ‐S is a brief, patient‐friendly tool with good reliability and validity, which may be useful for monitoring ICS side‐effects in clinical practice.