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Prevalence of atopy, eosinophilia, and IgE elevation in IgG4‐related disease
Author(s) -
Della Torre E.,
Mattoo H.,
Mahajan V. S.,
Carruthers M.,
Pillai S.,
Stone J. H.
Publication year - 2014
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12320
Subject(s) - atopy , eosinophilia , immunoglobulin e , medicine , immunology , allergy , immunopathology , epidemiology , disease , antibody
Abstract IgG4‐related disease ( I g G 4‐ RD ) is a fibroinflammatory disorder that can affect virtually every organ system. T‐helper type 2 responses have been presumed to be pathogenic in this disease, and a high proportion of patients with I g G 4‐ RD are reported to have longstanding allergies, peripheral blood eosinophilia, and serum I g E elevation. It has therefore been proposed that allergic mechanisms drive I g G 4‐ RD . However, no epidemiological assessment of atopy, peripheral blood eosinophilia, and serum IgE concentrations has ever been undertaken in patients with I g G 4‐ RD . In this study, we evaluated these parameters in a large cohort of patients with I g G 4‐ RD in whom a wide range of organs were affected by disease. Our results demonstrate that the majority of patients with I g G 4‐ RD are nonatopic. Nevertheless, a subset of nonatopic subjects exhibit peripheral blood eosinophilia and elevated I g E , suggesting that processes inherent to IgG4‐ RD itself rather than atopy per se contribute to the eosinophilia and I g E elevation observed in the absence of atopy.