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GSTP 1 is a hub gene for gene–air pollution interactions on childhood asthma
Author(s) -
Su M. W.,
Tsai C. H.,
Tung K. Y.,
Hwang B. F.,
Liang P. H.,
Chiang B. L.,
Yang Y. H.,
Lee Y. L.
Publication year - 2013
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12298
Subject(s) - gstp1 , air pollution , asthma , pollutant , environmental health , pollution , population , medicine , environmental science , gene , immunology , biology , genetics , ecology , genotype
There is growing evidence that multiple genes and air pollutants are associated with asthma. By identifying the effect of air pollution on the general population, the effects of air pollution on childhood asthma can be better understood. We conducted the T aiwan C hildren H ealth S tudy ( TCHS ) to investigate the influence of gene–air pollution interactions on childhood asthma. Complete monitoring data for the ambient air pollutants were collected from T aiwan E nvironmental P rotection A gency air monitoring stations. Our results show a significant two‐way gene–air pollution interaction between glutathione S ‐transferase P ( GSTP 1 ) and PM 10 on the risk of childhood asthma. Interactions between GSTP 1 and different types of air pollutants have a higher information gain than other gene–air pollutant combinations. Our study suggests that interaction between GSTP 1 and PM 10 is the most influential gene–air pollution interaction model on childhood asthma. The different types of air pollution combined with the GSTP 1 gene may alter the susceptibility to childhood asthma. It implies that GSTP 1 is an important hub gene in the anti‐oxidative pathway that buffers the harmful effects of air pollution.