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Nonallergic comorbidities of atopic eczema: an overview of systematic reviews
Author(s) -
Deckert S.,
Kopkow C.,
Schmitt J.
Publication year - 2014
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12246
Subject(s) - medicine , systematic review , observational study , medline , diabetes mellitus , checklist , comorbidity , asthma , disease , pediatrics , endocrinology , psychology , political science , law , cognitive psychology
The aims of this overview are to synthesize the current evidence of published systematic reviews ( SR s) on nonallergic comorbidities of atopic eczema ( AE ). EMBASE and MEDLINE were searched for SR s published from inception to November 2012. SR s were selected independently based on predefined inclusion criteria. Methodological quality of SR s included was assessed by two independent reviewers using the R evised A ssessment of M ultiple S ystematic R eviews ( R ‐ AMSTAR ) checklist. Nine SR s met all inclusion criteria. Six reviews addressing the association between AE and cancer suggest a decreased risk of glioma, meningioma, and acute lymphoblastic leukemia in patients with current or previous AE . One SR reported a consistent positive association of AE with attention‐deficit hyperactivity disorder ( ADHD ). Diabetes mellitus type 1 and multiple sclerosis ( MS ) were not significantly related to AE in reviews based on cross‐sectional and case–control studies. Patients with AE appear to be at decreased risk of brain tumors. The relationship of AE with Th1‐ and Th17‐mediated (auto‐)inflammatory conditions such as diabetes mellitus type 1 and MS should be clarified in prospective observational studies. Children with AE are at increased risk of ADHD . SR s on the risk of depression and Th17‐mediated disorders such as inflammatory bowel disease of patients with AE are missing.