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Serum allergen‐specific I g A is not associated with natural or induced tolerance to egg in children
Author(s) -
VazquezOrtiz M.,
Pascal M.,
Juan M.,
Alsina L.,
MartínMateos M. A.,
Plaza A. M.
Publication year - 2013
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12217
Subject(s) - ovalbumin , immunology , oral immunotherapy , egg allergy , allergy , medicine , pea protein , oral tolerance , biology , food allergy , food science , antigen
The role of specific I gA ( sIgA ) in oral immunotherapy ( OIT ) and natural tolerance to foods is poorly understood. We aimed to study serum sIgA in induced and natural tolerance to egg. Children aged 5–16 years diagnosed with I gE‐mediated egg allergy were recruited. After egg challenge, patients were classified as transient ( TEA ) or persistent ( PEA ) egg‐allergic. PEA children were further divided into oral immunotherapy ( PEA ‐ OIT ) or egg avoidance ( PEA ‐ EA ). Allergy/tolerance was reassessed 9–12 months later (T1) in PEA ‐ EA . Serum sIgA to ovalbumin and ovomucoid were determined at inclusion in all patients and repeated in PEA at T1. 21 TEA and 52 PEA children were recruited (28 PEA ‐OIT, 24 PEA ‐EA). Serum sIgA remained unchanged after OIT . TEA and PEA had similar serum sIgA . No specific trend on serum sIgA was observed in five PEA ‐ EA who developed natural tolerance over follow‐up. Thus, serum sIgA seems not to be associated with induced or natural egg tolerance.