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Allergy to betalactams and nucleotide‐binding oligomerization domain ( NOD ) gene polymorphisms
Author(s) -
Bursztejn A. C.,
Romano A.,
GuéantRodriguez R. M.,
Cornejo J. A.,
Oussalah A.,
Chery C.,
Gastin I.,
Gaeta F.,
Barbaud A.,
Blanca M.,
Guéant J. L.
Publication year - 2013
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12196
Subject(s) - nod2 , atopy , single nucleotide polymorphism , allergy , nod , allele , genotype , nod1 , immunology , immunoglobulin e , biology , genetics , medicine , gene , immune system , innate immune system , antibody
Background Polymorphisms of interleukin genes related to IgE production and inflammation are predictors of hypersensitivity to betalactam, but nothing is known on the influence of NOD genes, despite their association with inflammation and atopy. Objective To evaluate the association of NOD 2 and NOD 1 polymorphisms with betalactam allergy. Method We genotyped 3 polymorphisms of NOD 2 and 1 of NOD 1 in 368 Italian and 387 Spanish patients, compared with 368 and 326 controls, respectively. Results CT / TT genotypes of rs2066845 of NOD 2 predicted a lower risk in Italy ( P = 0.003), while WT /insC genotype of rs5743293 (also in leucine‐rich repeat domain) predicted a higher risk in Spain ( P = 0.007). G allele of rs2066845 was associated with a higher level of IgE in the Italian population. Conclusion The mirrored influence of these NOD 2 polymorphisms on betalactam allergy in two populations suggests a link with pathways of inflammation and/or atopy through mechanisms, which need to be clarified.