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Atopy patch tests are useful to predict oral tolerance in children with gastrointestinal symptoms related to non‐IgE‐mediated cow's milk allergy
Author(s) -
Nocerino R.,
Granata V.,
Di Costanzo M.,
Pezzella V.,
Leone L.,
Passariello A.,
Terrin G.,
Troncone R.,
Berni Canani R.
Publication year - 2013
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12071
Subject(s) - atopy , medicine , oral food challenge , cow's milk allergy , allergy , immunoglobulin e , milk allergy , gastroenterology , immunology , food allergy , pediatrics , antibody
Atopy patch tests ( APT s) have been proposed for the diagnostic approach in children with non‐IgE‐mediated cow's milk allergy and gastrointestinal symptoms. We aimed to investigate the benefit of APT s in predicting oral tolerance in these patients. We prospectively evaluated 172 subjects with a sure diagnosis of non‐IgE‐mediated CMA and gastrointestinal symptoms (97 boys, 56.4%; age, 6.37 m; range, 2–12 m). At diagnosis, 113/172 (65.7%) children had positive APT s to cow's milk proteins ( CMP ). After 12 months of exclusion, diet APT s were repeated immediately before OFC . APT s significantly correlated ( P < 0.001) with the OFC outcome (r 0.579). Diagnostic accuracy was sensitivity of 67.95%, specificity of 88.3%, PPV of 82.81%, NPV of 76.85%, and a + LR of 5.80. APT s are a valuable tool in the follow‐up of children with non‐IgE‐mediated CMA ‐related gastrointestinal symptoms by contributing in determining whether an OFC can safely be undertaken.