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Semi‐direct alloantigen presentation detected in human liver but not kidney transplant recipients: Implications for the future
Author(s) -
Burlingham Will,
Chapman Will
Publication year - 2021
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.16524
Subject(s) - medicine , immunology , downregulation and upregulation , transplantation , major histocompatibility complex , antigen presentation , antigen , host (biology) , organ transplantation , t cell , immune system , biology , gene , biochemistry , ecology
Circulating host dendrictic cells (DCs) acquire donor MHC antigens either immediately after liver transplantation (Mastoridis et al., page 2387) or after host pretreatment with 'immature' donor‐derived DCs (Macedo et al., page 2372), resulting in a unique tolerogenic signal, although, in the latter, host DCs acquire both donor MHC and PD‐L1, triggering downregulation of host alloreactive T cells.