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COVID‐19 in pediatric kidney transplantation: The Improving Renal Outcomes Collaborative
Author(s) -
Varnell Charles,
Harshman Lyndsay A.,
Smith Laurie,
Liu Chunyan,
Chen Shiran,
AlAkash Samhar,
Barletta GinaMarie,
Belsha Craig,
Brakeman Paul,
Chaudhuri Abanti,
Fadakar Paul,
Garro Rouba,
Gluck Caroline,
Goebel Jens,
Kershaw David,
Matossian Debora,
Nailescu Corina,
Patel Hiren P.,
Pruette Cozumel,
Ranabothu Saritha,
Rodig Nancy,
Smith Jodi,
Sebestyen VanSickle Judith,
Weng Patricia,
DanzigerIsakov Lara,
Hooper David K.,
Seifert Michael
Publication year - 2021
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.16501
Subject(s) - medicine , incidence (geometry) , asymptomatic , transplantation , prospective cohort study , kidney transplantation , cohort , covid-19 , cohort study , pediatrics , intensive care medicine , emergency medicine , disease , infectious disease (medical specialty) , physics , optics
There are limited data on the impact of COVID‐19 in children with a kidney transplant (KT). We conducted a prospective cohort study through the Improving Renal Outcomes Collaborative (IROC) to collect clinical outcome data about COVID‐19 in pediatric KT patients. Twenty‐two IROC centers that care for 2732 patients submitted testing and outcomes data for 281 patients tested for SARS‐CoV‐2 by PCR. Testing indications included symptoms and/or potential exposures to COVID‐19 ( N = 134, 47.7%) and/or testing per hospital policy ( N = 154, 54.8%). Overall, 24 (8.5%) patients tested positive, of which 15 (63%) were symptomatic. Of the COVID‐19‐positive patients, 16 were managed as outpatients, six received non‐ICU inpatient care and two were admitted to the ICU. There were no episodes of respiratory failure, allograft loss, or death associated with COVID‐19. To estimate incidence, subanalysis was performed for 13 centers that care for 1686 patients that submitted all negative and positive COVID‐19 results. Of the 229 tested patients at these 13 centers, 10 (5 asymptomatic) patients tested positive, yielding an overall incidence of 0.6% and an incidence among tested patients of 4.4%. Pediatric KT patients in the United States had a low estimated incidence of COVID‐19 disease and excellent short‐term outcomes.