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An early experience on the effect of solid organ transplant status on hospitalized COVID‐19 patients
Author(s) -
Nair Vinay,
Jandovitz Nicholas,
Hirsch Jamie S.,
Abate Mersema,
Satapathy Sanjaya K.,
Roth Nitzan,
Miyara Santiago J.,
Guevara Sara,
Kressel Adam M.,
Xiang Alec,
Wu Grace,
Butensky Samuel D.,
Lin David,
Williams Stephanie,
Bhaskaran Madhu C.,
Majure David T.,
Grodstein Elliot,
Lau Lawrence,
Nair Gayatri,
Fahmy Ahmed E.,
Winnick Aaron,
Breslin Nadine,
Berlinrut Ilan,
Molmenti Christine,
Becker Lance B.,
Malhotra Prashant,
GautamGoyal Pranisha,
Lima Brian,
Maybaum Simon,
Shah Samit K.,
Takegawa Ryosuke,
Hayashida Kei,
Shinozaki Koichiro,
Teperman Lewis W.,
Molmenti Ernesto P.
Publication year - 2021
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.16460
Subject(s) - medicine , comorbidity , mechanical ventilation , odds ratio , immunosuppression , logistic regression , multivariate analysis , clinical endpoint , population , randomized controlled trial , environmental health
We compared the outcome of COVID‐19 in immunosuppressed solid organ transplant (SOT) patients to a transplant naïve population. In total, 10 356 adult hospital admissions for COVID‐19 from March 1, 2020 to April 27, 2020 were analyzed. Data were collected on demographics, baseline clinical conditions, medications, immunosuppression, and COVID‐19 course. Primary outcome was combined death or mechanical ventilation. We assessed the association between primary outcome and prognostic variables using bivariate and multivariate regression models. We also compared the primary endpoint in SOT patients to an age, gender, and comorbidity‐matched control group. Bivariate analysis found transplant status, age, gender, race/ethnicity, body mass index, diabetes, hypertension, cardiovascular disease, COPD, and GFR <60 mL/min/1.73 m 2 to be significant predictors of combined death or mechanical ventilation. After multivariate logistic regression analysis, SOT status had a trend toward significance (odds ratio [OR] 1.29; 95% CI 0.99–1.69, p = .06). Compared to an age, gender, and comorbidity‐matched control group, SOT patients had a higher combined risk of death or mechanical ventilation (OR 1.34; 95% CI 1.03–1.74, p = .027).