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Meta‐analysis and meta‐regression of outcomes for adult living donor liver transplantation versus deceased donor liver transplantation
Author(s) -
Barbetta Arianna,
Aljehani Mayada,
Kim Michelle,
Tien Christine,
Ahearn Aaron,
Schilperoort Hannah,
Sher Linda,
Emamaullee Juliet
Publication year - 2021
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.16440
Subject(s) - medicine , liver transplantation , transplantation , surgery , living donor liver transplantation , model for end stage liver disease , portal vein thrombosis , survival rate , thrombosis , gastroenterology
Prior single center or registry studies have shown that living donor liver transplantation (LDLT) decreases waitlist mortality and offers superior patient survival over deceased donor liver transplantation (DDLT). The aim of this study was to compare outcomes for adult LDLT and DDLT via systematic review. A meta‐analysis was conducted to examine patient survival and graft survival, MELD, waiting time, technical complications, and postoperative infections. Out of 8600 abstracts, 19 international studies comparing adult LDLT and DDLT published between 1/2005 and 12/2017 were included. U.S. outcomes were analyzed using registry data. Overall, 4571 LDLT and 66,826 DDLT patients were examined. LDLT was associated with lower mortality at 1, 3, and 5 years posttransplant (5‐year HR 0.87 [95% CI 0.81–0.93], p < .0001), similar graft survival, lower MELD at transplant ( p < .04), shorter waiting time ( p < .0001), and lower risk of rejection ( p = .02), with a higher risk of biliary complications (OR 2.14, p < .0001). No differences were observed in rates of hepatic artery thrombosis. In meta‐regression analysis, MELD difference was significantly associated with posttransplant survival ( R 2 0.56, p = .02). In conclusion, LDLT is associated with improved patient survival, less waiting time, and lower MELD at LT, despite posing a higher risk of biliary complications that did not affect survival posttransplant.