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Alternative strategies of posttransplant influenza vaccination in adult solid organ transplant recipients
Author(s) -
Haddadin Zaid,
Krueger Karen,
Thomas Lora D.,
Overton Edgar T.,
Ison Michael,
Halasa Natasha
Publication year - 2021
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.16295
Subject(s) - medicine , vaccination , immunogenicity , immunology , organ transplantation , influenza vaccine , immune system , intensive care medicine , population , disease , transplantation , environmental health
Solid organ transplant (SOT) recipients are at increased risk of influenza disease and associated complications. The mainstay of prevention is the annual standard‐dose influenza vaccine, as studies showed decreased influenza‐related morbidity and mortality in vaccinated SOT recipients compared to those unvaccinated. Nonetheless, the immune response in this high‐risk population is suboptimal compared to healthy individuals. Over the past two decades, several vaccination strategies have been investigated to overcome this inadequate immune response in SOT recipients. Howbeit, the best vaccination strategy and optimal timing of influenza vaccination remain unclear. This review will provide a detailed summary of studies of various influenza vaccination strategies in adult SOT recipients, discussing immunogenicity results, and addressing their limitations and knowledge gaps.