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Increased risk of neonatal complications and infections in children of kidney‐transplanted women: A nationwide controlled cohort study
Author(s) -
Egerup Pia,
Carlson Nicholas,
Bruun Oestergaard Louise,
Blanche Paul,
Scott James R.,
Hornum Mads,
TorpPedersen Christian,
Christiansen Ole Bjarne
Publication year - 2021
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.16259
Subject(s) - medicine , relative risk , cohort study , low birth weight , offspring , confidence interval , population , birth weight , pediatrics , cohort , obstetrics , retrospective cohort study , pregnancy , environmental health , biology , genetics
Information related to short‐ and long‐term risks of children born to kidney‐transplanted women remains limited. With the aim of investigating the risk of neonatal complications, and the short‐ and long‐term risk of infections in offspring of kidney‐transplanted women, all children born to kidney‐transplanted women in Denmark from 1964 to 2016 were identified in a nationwide retrospective matched cohort study. A total of 124 children of kidney‐transplanted women were identified and matched on gender, birth year, and number of siblings at birth 1:10 with children born to nontransplanted women identified in the Danish general population. Prevalence of low birth weight (37.9%, risk ratio [RR] = 12.61; 95% confidence interval [CI], 8.5‐18.5), premature birth (46.0%, RR = 11.32; 95% CI, 8.1‐15.7) and malformations (11.3%, RR = 1.98; 95% CI, 1.2‐3.4) was increased in children of kidney‐transplanted women compared with controls. Similarly, prevalence of hospitalization due to infection was increased during the first year of life (21.0%, RR = 1.94; 95% CI, 1.3‐2.8), from age 1 to 5 (34.2%, RR = 1.89; 95% CI, 1.4‐2.5), and overall (41.9%, RR = 1.67; 95% CI, 1.3‐2.1). The risk of infection was also higher in children of kidney‐transplanted mothers born preterm or with low birth weight compared with similar controls. In conclusion, risk of neonatal complications, malformations, and both early and late infection were increased in children born to kidney‐transplanted women.