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B cells and extracellular vesicles: New key players in solid organ transplantation?
Author(s) -
Colas Luc,
Brouard Sophie
Publication year - 2021
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.16253
Subject(s) - transplantation , immunology , context (archaeology) , cd8 , antigen presentation , antigen , major histocompatibility complex , immune system , medicine , organ transplantation , microbiology and biotechnology , t cell , biology , paleontology
In the context of solid organ transplantation, Becker et al. ( page 1415) show that semidirect presentation of donor MHC antigens acquired from donor extracellular vesicles by recipient B cells can initiate the alloimmune response, thus challenging the canonical passenger leukocyte theory.
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