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Clinical outcomes and serologic response in solid organ transplant recipients with COVID‐19: A case series from the United States
Author(s) -
Fung Monica,
Chiu Charles Y.,
DeVoe Catherine,
Doernberg Sarah B.,
Schwartz Brian S.,
Langelier Charles,
Henrich Timothy J.,
Yokoe Deborah,
Davis John,
Hays Steven R.,
Chandran Sindhu,
Kukreja Jasleen,
Ng Dianna,
Prostko John,
Taylor Russell,
Reyes Kevin,
Bainbridge Emma,
Bond Allison,
ChinHong Peter,
Babik Jennifer M.
Publication year - 2020
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.16079
Subject(s) - medicine , serology , pandemic , disease , population , intensive care medicine , covid-19 , transplantation , immunology , infectious disease (medical specialty) , antibody , environmental health
The coronavirus disease 2019 (COVID‐19) pandemic caused by SARS coronavirus 2 (SARS‐CoV‐2) has caused significant morbidity and mortality for patients and stressed healthcare systems worldwide. The clinical features, disease course, and serologic response of COVID‐19 among immunosuppressed patients such as solid organ transplant (SOT) recipients, who are at presumed risk for more severe disease, are not well characterized. We describe our institutional experience with COVID‐19 among 10 SOT patients, including the clinical presentation, treatment modalities, and outcomes of 7 renal transplant recipients, 1 liver transplant recipient, 1 heart transplant recipient, and 1 lung transplant recipient. In addition, we report the serologic response in SOT recipients, documenting a positive IgG response in all 7 hospitalized patients. We also review the existing literature on COVID‐19 in SOT recipients to consolidate the current knowledge on COVID‐19 in the SOT population for the transplant community.