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Clinical characteristics and immunosuppressant management of coronavirus disease 2019 in solid organ transplant recipients
Author(s) -
Zhong Zibiao,
Zhang Qiuyan,
Xia Haoyang,
Wang Aiping,
Liang Wenjin,
Zhou Wei,
Zhou Lihua,
Liu Xiao,
Rao Lingzhang,
Li Zhifeng,
Peng Zhiyong,
Mo Pingzheng,
Xiong Yong,
Ye Shaojun,
Wang Yanfeng,
Ye Qifa
Publication year - 2020
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15928
Subject(s) - medicine , regimen , methylprednisolone , transplantation , surgery , gastroenterology
Over 1 000 000 cases of coronavirus disease 2019 (COVID‐19) have been confirmed since the worldwide outbreak began. Not enough data on infected solid organ transplant (SOT) recipients are available, especially data about the management of immunosuppressants. We report two cases of COVID‐19 in two transplant recipients, with different treatments and prognoses. The first patient received liver transplantation due to hepatitis B virus–related hepatocellular carcinoma and was confirmed to have COVID‐19 9 days later. Following a treatment regimen consisting of discontinued immunosuppressant use and low‐dose methylprednisolone‐based therapy, the patient developed acute rejection but eventually recovered. The other patient had undergone a renal transplant from a living‐related donor 17 years ago, and was admitted to the hospital because of persistent fever. This patient was also diagnosed with COVID‐19. His treatment regimen consisted of reduced immunosuppressant use. No signs of rejection were observed during the regimen. In the end, the patient successfully recovered from COVID‐19. These effectively treated cases can provide a basis for immunosuppressant management of COVID‐19‐positive SOT recipients.