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FcγRIIB, a new checkpoint to halt alloreactive memory T cells
Author(s) -
Cravedi Paolo
Publication year - 2020
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15854
Subject(s) - medicine , immunology , neuroscience , biology
Morris et al ( page 2206) newly report that memory CD8 + T cells, the main mediators of alloimmune response, express the checkpoint molecule FcγRIIB, which controls their activation and survival and therefore represents a potential therapeutic target for selective antirejection therapies.