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American Journal of Transplantation: Volume 20, Number 4, April 2020
Publication year - 2020
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15838
Subject(s) - medicine , transplantation , volume (thermodynamics) , surgery , quantum mechanics , physics
On the cover: Histology has long been a mainstay of transplant diagnostics. However, its role in mechanistic research is accentuated in an article by Calvani et al ( page 942). In this study, the authors use an innovative technology of multiplexed immunofluorescence on paraffin‐embedded biopsies to simultaneously detect NK cells, macrophages, and T cells and to determine their intra‐ or extravascular localization during T cell‐ and antibody‐mediated rejection. The implications of this fine work are highlighted in a thoughtful editorial by Bellamy and Prost ( page 915), who discuss the opportunities and practicalities of this “next‐generation pathology” to reveal unsuspected networks of spatial, social, and functional cellular organization.