Premium
Lymphatic vessels in solid organ transplantation and immunobiology
Author(s) -
Wong Brian W.
Publication year - 2020
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15806
Subject(s) - lymphatic system , lymphangiogenesis , context (archaeology) , medicine , transplantation , pathology , organ transplantation , inflammation , immunology , biology , cancer , metastasis , paleontology
With the recent advances in our understanding of the function and biology of the lymphatic vascular system, it is clear that the lymphatic system plays an integral role in physiology, and in pathological settings, may contribute to either enhance or repress inflammation and disease progression. Inflammation is central to both acute and chronic rejection in the context of solid organ transplantation, and emerging evidence suggests the lymphatic system plays a key role in shaping outcomes. The goals of this review are to highlight and contextualize the roles of lymphatic vessels and lymphangiogenesis in immunobiology, the impact immunosuppressive therapies have on the lymphatic system and emerging evidence of organ‐specific heterogeneity of lymphatic vessels in the context of solid organ transplantation.