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In vivo and in vitro differences in CD8 + T cell metabolism
Author(s) -
Allocco Jennifer B.,
Alegre MariaLuisa
Publication year - 2020
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15781
Subject(s) - in vivo , in vitro , microbiology and biotechnology , medicine , cd8 , stimulation , metabolism , biology , immunology , immune system , biochemistry , endocrinology , genetics
CD8 + T cells activated in vivo display different metabolic profiles than those stimulated in vitro, underscoring the key role of the environment in dictating metabolic pathways downstream of T cell receptor stimulation.