Premium
Amphiregulin as a driver of tissue fibrosis
Author(s) -
Zaiss Dietmar M. W.
Publication year - 2020
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15743
Subject(s) - amphiregulin , medicine , myofibroblast , fibrosis , extracellular matrix , lung , epidermal growth factor , pulmonary fibrosis , potentiator , pathology , growth factor , cancer research , transforming growth factor , epidermal growth factor receptor , immunology , cancer , biology , microbiology and biotechnology , receptor
Todd et al ( page 825) show that the epidermal growth factor–like growth factor amphiregulin is significantly more expressed in the lungs of lung transplant patients who develop chronic lung allograft dysfunction than in those who do not, suggesting that blocking amphiregulin might be a novel therapeutic approach to prevent the loss of transplanted organs.