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The initiation of graft‐versus‐host disease
Author(s) -
Alegre MariaLuisa
Publication year - 2020
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15731
Subject(s) - graft versus host disease , immunology , major histocompatibility complex , mhc class i , transplantation , mhc class ii , minor histocompatibility antigen , t cell , stem cell , immune system , cytotoxic t cell , hematopoietic stem cell transplantation , medicine , biology , microbiology and biotechnology , in vitro , biochemistry
A microbiota IL‐12‐IFN‐γ axis after total body irradiation for bone marrow transplantation results in MHC class II upregulation on ileal epithelial cells, activating donor alloreactive CD4 + T cells and initiating gut GVHD in mice.