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Interleukin‐7 receptor blockade by an anti‐ CD 127 monoclonal antibody in nonhuman primate kidney transplantation
Author(s) -
Mai Hoa Le,
Nguyen Thi Van Ha,
Branchereau Julien,
Poirier Nicolas,
Renaudin Karine,
Mary Caroline,
Belarif Lyssia,
Minault David,
Hervouet Jeremy,
Le BasBerdardet Stéphanie,
Soulillou JeanPaul,
Vanhove Bernard,
Blancho Gilles,
Brouard Sophie
Publication year - 2020
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15543
Subject(s) - interleukin 7 receptor , medicine , thymoglobulin , blockade , immunology , kidney transplantation , transplantation , kidney , monoclonal antibody , basiliximab , t cell , receptor , pharmacology , immune system , antibody , il 2 receptor
IL ‐7 is an important cytokine for T cell lymphopoiesis. Blockade of the IL ‐7 signaling pathway has been shown to induce long‐term graft survival or graft tolerance in murine transplant models through inhibiting T cell homeostasis and favoring immunoregulation. In this study, we assessed for the first time the effects of a blocking anti‐human cluster of differentiation 127 (CD 127) mA b administered in combination with low‐dose tacrolimus or thymoglobulin in a life‐sustaining kidney allograft model in baboons. Contrary to our expectation, the addition of an anti‐ CD 127 mA b to the treatment protocols did not prolong graft survival compared to low‐dose tacrolimus alone or thymoglobulin alone. Anti‐ CD 127 mA b administration led to full CD 127 receptor occupancy during the follow‐up period. However, all treated animals lost their kidney graft between 1 week and 2 weeks after transplantation. Unlike in rodents, in nonhuman primates, anti‐ CD 127 mA b treatment does not decrease the absolute numbers of lymphocyte and lymphocyte subsets and does not effectively inhibit postdepletional T cell proliferation and homeostasis, suggesting that IL ‐7 is not a limiting factor for T cell homeostasis in primates.