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Teamwork by IL ‐10+ and IL ‐35 + T regs
Author(s) -
McIntosh Christine M.,
Alegre MariaLuisa
Publication year - 2019
Publication title -
american journal of transplantation
Language(s) - French
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15511
Subject(s) - foxp3 , tumor microenvironment , immunology , immune system , downregulation and upregulation , cancer research , immune tolerance , t cell , context (archaeology) , medicine , biology , paleontology , biochemistry , gene
Distinct populations of IL‐10– and IL‐35–producing Treg cells in the tumor microenvironment cooperatively promote upregulation of BLIMP1 and exhaustion of tumor‐infiltrating conventional T cells.
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