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Clinical importance of the updated Oxford classification in allograft IgA nephropathy
Author(s) -
Park Sehoon,
Go Heounjeong,
Baek Chung Hee,
Kim Young Hoon,
Kim Yong Chul,
Yang Seung Hee,
Lee Jung Pyo,
Min Sang–il,
Ha Jongwon,
Song Eun Young,
Kim Yon Su,
Park SuKil,
Lee Hajeong,
Moon Kyung Chul
Publication year - 2019
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15400
Subject(s) - medicine , nephropathy , retrospective cohort study , cohort , proportional hazards model , clinical significance , disease , gastroenterology , surgery , diabetes mellitus , endocrinology
With the recent update to the Oxford classification for allograft IgA nephropathy (Ig AN ), additional investigations on the clinical significance of the updated components are warranted. We performed a retrospective cohort study at two tertiary hospitals. Kidney transplant recipients diagnosed with allograft Ig AN were included in the study after additional review by specialized pathologists. We applied the updated Oxford classification and determined the MEST ‐C scores of the patients. The main study outcome was death‐censored graft failure within 10 years after the establishment of allograft Ig AN diagnosis and was assessed using the Cox regression analysis. Three hundred thirty‐three allograft Ig AN patients were reviewed: 100 patients with confirmed native Ig AN and 233 patients with other, clinical, or unknown primary causes for end‐stage renal disease ( ESRD ). The updated Oxford classification for allograft Ig AN demonstrated prognostic value for graft failure, and patients with multiple MEST ‐C components had worse outcomes. M, E, S, and C were significantly associated with the prognosis of recurred Ig AN and T was the only independent prognostic parameter for allograft Ig AN without confirmed native Ig AN . Therefore, we suggest reporting MEST ‐C scores in allograft biopsies and careful interpretation of the results according to the primary cause of ESRD .