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Transfer of donor anti‐ HLA antibody expression to multiple transplant recipients: A potential variant of the passenger lymphocyte syndrome?
Author(s) -
Kummrow Megan,
Hiho Steven,
Hudson Fiona,
Cantwell Linda,
Mulley William R.,
D'Orsogna Lloyd,
Testro Adam,
Pavlovic Julie,
MacDonald Peter,
Sullivan Lucy C.,
Snell Gregory I.,
Westall Glen P.
Publication year - 2019
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15262
Subject(s) - human leukocyte antigen , immunology , antibody , medicine , lymphocyte , immune system , transplantation , antigen , donor specific antibodies
Antibody‐mediated rejection, whereby transplant recipient B cells and/or plasma cells produce alloreactive anti‐human leukocyte antigen ( HLA ) antibodies, negatively influences transplant outcomes and is a major contributor to graft loss. An early humoral immune response is suggested by the production of anti‐ HLA donor‐specific antibodies ( DSA ) that can be measured using solid phase assays. We report the early posttransplant coexistence of a shared anti‐ HLA antibody profile in 5 solid organ transplant recipients who received organs from the same donor. Retrospective analysis of the donor's serum confirmed the presence of the same anti‐ HLA profile, suggesting the transfer of donor‐derived anti‐ HLA antibodies, or the cells that produce them, to multiple solid organ transplant recipients. The time frame and extent of transfer suggest a novel variant of the passenger lymphocyte syndrome. These findings have important implications for the consideration of all posttransplant antibody measurements, particularly the interpretation of non‐ DSA s in the sera of transplant recipients.