Premium
The Importance of Inflammation‐induced NETS
Author(s) -
Alegre MariaLuisa
Publication year - 2019
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15210
Subject(s) - proteases , inflammation , medicine , laminin , integrin , cancer research , microbiology and biotechnology , immunology , receptor , extracellular matrix , biology , biochemistry , enzyme
NETs induced during inflammation display proteases that can induce a conformation change in local laminin, which activates integrins in dormant cancer cells, resulting in their awakening, proliferation, and metastases establishment.