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Repeat kidney transplant recipients with active rejection have elevated donor‐derived cell‐free DNA
Author(s) -
Mehta Shikha G.,
Chang Jae H.,
Alhamad Tarek,
Bromberg Jonathan S.,
Hiller David J.,
Grskovic Marica,
Yee James P.,
Man Roslyn B.
Publication year - 2019
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15192
Subject(s) - medicine , cell free fetal dna , kidney transplant , dna , renal transplant , kidney transplantation , kidney , immunology , genetics , biology , pregnancy , fetus , prenatal diagnosis
In 2015, 13% of recipients of kidney transplants in the United States were repeat transplants for prior allograft failure (1). These repeat kidney transplant recipients (RKTR) have inferior graft survival and a higher risk of rejection to that of single kidney transplant recipients (SKTR) (1, 2). In spite of these risks, transplant patients benefit from a repeat transplant compared to dialysis support (3). The use of noninvasive biomarkers of allograft injury may optimize the care of RKTR. This article is protected by copyright. All rights reserved.