Premium
Mast cells contribute to the induction of ocular mucosal alloimmunity
Author(s) -
Li Mingshun,
Mittal Sharad K.,
Foulsham William,
Amouzegar Afsaneh,
Sahu Srikant K.,
Chauhan Sunil K.
Publication year - 2019
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15084
Subject(s) - alloimmunity , immunology , medicine , immune system , mast cell , infiltration (hvac) , transplantation , innate lymphoid cell , innate immune system , microbiology and biotechnology , biology , physics , thermodynamics
Beyond their historical role as the effector cells in allergic disorders, mast cells have been implicated in regulating both innate and adaptive immune responses. Possessing considerable functional plasticity, mast cells are abundant at mucosal surfaces, where the host and external environments interface. The purpose of this study was to evaluate the contribution of mast cells to allograft rejection at the ocular surface. Using a well‐characterized murine model of corneal transplantation, we report that mast cells promote allosensitization. Our data show mast cell frequencies and activation are increased following transplantation. We demonstrate that mast cell inhibition (a) limits the infiltration of inflammatory cells and APC maturation at the graft site; (b) reduces allosensitization and the generation of Th1 cells in draining lymphoid tissues; (c) decreases graft infiltration of alloimmune‐inflammatory cells; and (d) prolongs allograft survival. Our data demonstrate a novel function of mast cells in promoting allosensitization at the ocular surface.