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No impact of disseminated intravascular coagulation in kidney donors on long‐term kidney transplantation outcome: A multicenter propensity‐matched study
Author(s) -
Garrouste Cyril,
Baude Julien,
Gatault Philippe,
Pereira Bruno,
Etienne Isabelle,
Thierry Antoine,
Szlavik Nora,
Aniort Julien,
Rabant Marion,
Lambert Céline,
Sayegh Johnny,
Oniszczuk Julie,
Anglicheau Dany,
Heng Anne Elisabeth
Publication year - 2019
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15008
Subject(s) - contraindication , medicine , disseminated intravascular coagulation , transplantation , renal function , surgery , kidney transplantation , kidney , urology , pathology , alternative medicine
The diagnosis of disseminated intravascular coagulation (DIC) is often considered to be a contraindication to organ donation. The aim of this study was to evaluate the impact of DIC+ donors on kidney recipient (KR) evolution. We identified 169 KRs with DIC+ donation after brain death donors between January 1996 and December 2012 in 6 French transplant centers. Individuals were matched using propensity scores to 338 recipients with DIC− donors according to donor age and sex, whether expanded criteria for the donor existed, graft year, and transplantation center. After kidney transplantation, delayed graft function was observed in 28.1% of DIC+ KRs and in 22.8% of DIC− KRs (NS). Renal allograft survival at 1, 5, and 10 years was 94.5%, 89.3%, and 73.9% and 96.2%, 90.8%, and 81.3% in DIC+ KRs and DIC− KRs, respectively (NS). The median estimated glomerular filtration rate (eGFR) was similar between DIC+ and DIC− KRs at 3 months, 1 year, and 10 years: 45.9 vs 48.1 mL/min, 42.1 vs 43.1 mL/min, and 33.9 vs 38.1 mL/min, respectively. Delayed calcineurin inhibitor introduction or induction had no impact on delayed graft function rate or eGFR evolution at 10 years after transplantation in DIC+ KRs. Donor DIC did not seem to affect initial outcome, long‐term graft function, or allograft survival.