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Metabolic Control of T Cell Memory
Author(s) -
Mcintosh Christine M.,
Alegre MariaLuisa
Publication year - 2018
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.15001
Subject(s) - medicine , computational biology , biology
For optimal function upon restimulation, memory CD8+ T cells must increase their aerobic metabolic rate to promote the production of citrate, which can be converted to acetyl‐CoA outside of the mitochondrion and may be used as a substrate by histone acetyltransferases.