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Belatacept during pregnancy in renal transplant recipients: Two case reports
Author(s) -
Combs Jenna,
Kagan Anna,
Boelkins Mark,
Coscia Lisa,
Moritz Michael,
Hofmann R. Michael
Publication year - 2018
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14911
Subject(s) - medicine , belatacept , pregnancy , immunosuppression , miscarriage , obstetrics , kidney transplantation , transplantation , intensive care medicine , kidney transplant , biology , genetics
Impaired fertility is common among patients with chronic organ failure, including end‐stage renal disease (ESRD). Women of childbearing age undergoing transplantation may experience rapid return of fertility. Pregnancy posttransplant presents numerous risks for the patient, fetus, and allograft. Maternal risks include hypertension and preeclampsia. Allograft risks include acute rejection and failure of the organ, and fetal risks include miscarriage, birth defects from immunosuppressants, premature delivery, and low birth weight. Belatacept, a selective T cell costimulation blocker, was approved for use in kidney transplant recipients in the United States in 2011. Little is known about the safety of belatacept during pregnancy in humans. We describe 2 cases of successful pregnancy and delivery with the use of belatacept‐based immunosuppression. The Transplant Pregnancy Registry International (TPR) is a voluntary registry for transplant recipients who have had pregnancies or fathered a pregnancy posttransplant. To date, these 2 cases are the only known exposures to belatacept that have been reported to the TPR.[1][Rao S, 2016]