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Detection of chronic lung allograft dysfunction using ventilation‐weighted Fourier decomposition MRI
Author(s) -
Voskrebenzev A.,
Greer M.,
Gutberlet M.,
Schönfeld C.,
Renne J.,
Hinrichs J.,
Kaireit T.,
Welte T.,
Wacker F.,
Gottlieb J.,
VogelClaussen J.
Publication year - 2018
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14759
Subject(s) - medicine , magnetic resonance imaging , quartile , gradient echo , lung transplantation , transplantation , radiology , lung , nuclear medicine , confidence interval
Chronic lung allograft dysfunction (CLAD) remains the leading cause of morbidity and mortality after lung transplantation. Diagnosis requires spirometric change, which becomes increasingly difficult with advancing CLAD. Fourier decomposition magnetic resonance imaging (FD‐MRI) permits acquisition of ventilated‐weighted images during free‐breathing. This study evaluates FD‐MRI in detecting CLAD in selected patients after bilateral lung transplantation (DLTx). DLTx recipients demonstrating CLAD at various stages participated. Radiologists remained blinded to clinical status until completion of image analysis. Image acquisition used a 1.5‐T MR scanner using a spoiled gradient echo sequence. After FD processing and regional fractional ventilation (RFV) quantification, the volume defect percentage at 2 thresholds (VDP 1,2 ), median lung RFV and quartile coefficient of dispersion (QCD) were calculated. Sixty‐two patients participated. CLAD was present in 29/62 (47%) patients, of whom 17/62 (27%) had forced expiratory volume in 1 second ≤65% at image acquisition. VDP 1 was higher among these participants compared to other groups ( P < .001). Increased VDP 1 was associated with subsequent graft loss, with values >2% showing reduced survival, independent of degree of graft dysfunction ( P = .005). VDP 2 discriminated between presence or absence of CLAD (area under the curve = 0.71; P = .03). QCD increased significantly with advancing disease ( P < .001). In conclusion, FD‐MRI‐derived parameters demonstrate potential in quantitative CLAD diagnosis and assessment after DLTx.