American Journal of Transplantation: Volume 18, Number 4, April 2018

On the cover this month: Despite decades of progress, organ transplantation remains dominated by the efficacy and side effectsof calcineurin inhibitors. In this month's AJT, Benway and Iacomini ( page 796) map out the mRNA targetome of renal proximaltubule cells, exposing potential mechanisms of the nephrotoxicity that limits the utility of this class of drug. Also, see a unique assessment of emergency department utilization by Lovasik et al ( page 868) and a thoughtful editorial on this topic by Schold and Locke ( page 777). Cover image by Lauren Halligan, Duke University Department of Surgery.