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Dietary Approach to Stop Hypertension ( DASH ) diet and risk of renal function decline and all‐cause mortality in renal transplant recipients
Author(s) -
Osté Maryse C. J.,
GomesNeto António W.,
Corpeleijn Eva,
Gans Rijk O. B.,
de Borst Martin H.,
van den Berg Else,
SoedamahMuthu Sabita S.,
Kromhout Daan,
Navis Gerjan J.,
Bakker Stephan J. L.
Publication year - 2018
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14707
Subject(s) - medicine , hazard ratio , interquartile range , renal function , dash diet , risk factor , proportional hazards model , confidence interval , prospective cohort study , creatinine , blood pressure , surgery
Renal transplant recipients ( RTR ) are at risk of decline of graft function and premature mortality, with high blood pressure as an important risk factor for both. To study the association of the Dietary Approach to Stop Hypertension ( DASH ) diet with these adverse events, we conducted a prospective cohort study of adult RTR . Dietary data were collected using a validated 177‐item food frequency questionnaire and an overall DASH ‐score was obtained. We included 632 stable RTR (mean ± standard deviation age 53.0 ± 12.7 years, 57% men). Mean DASH score was 23.8 ± 4.7. During median follow‐up of 5.3 (interquartile range, 4.1‐6.0) years, 119 (18.8%) RTR had renal function decline, defined as a combined endpoint of doubling of serum creatinine and death‐censored graft failure, and 128 (20.3%) died. In Cox‐regression analyses, RTR in the highest tertile of the DASH score had lower risk of both renal function decline (hazard ratio [ HR ] = 0.57; 95% confidence interval [ CI ], 0.33‐0.96, P = .03) and all‐cause mortality ( HR = 0.52; 95% CI , 0.32‐0.83, P = .006) compared to the lowest tertile, independent of potential confounders. Adherence to a DASH ‐style diet is associated with lower risk of both renal function decline and all‐cause mortality. These results suggest that a healthful diet might benefit long‐term outcome in RTR .