Premium
Exercise capacity in young adults after hematopoietic cell transplantation in childhood
Author(s) -
Öberg Anders,
Genberg Margareta,
Malinovschi Andrei,
Hedenström Hans,
Frisk Per
Publication year - 2018
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14456
Subject(s) - medicine , transplantation , hematopoietic stem cell transplantation , young adult , workload , lean body mass , total body irradiation , pulmonary function testing , gastroenterology , body weight , chemotherapy , cyclophosphamide , computer science , operating system
A symptom‐limited incremental cycle ergometer test was performed in 17 young adult patients treated with hematopoietic cell transplantation and total body irradiation for hematologic malignancies during childhood. These 17 young adult patients were compared with 17 sex‐ and age‐matched healthy control subjects. Assessments of pulmonary function, cardiac function, body composition, and levels of growth hormone were made. The median follow‐up was 17.7 years. Patients achieved 63.2% of the predicted peak workload, whereas controls achieved 96.1% ( P < .001). All patients, but only 1 control, failed to achieve a peak workload >80% ( P < .001). Fat‐free mass was significantly lower (43.5 vs 57.6 kg, P < .001) and fat mass percentage was significantly higher (31.8% vs 24.2%, P = .011) in the patients. The peak workload adjusted for fat‐free mass was significantly lower in the patients (3.3 vs 4.3, P < .001). In the patients, peak workload correlated significantly with total lung capacity ( r = .54, P = .025). In summary, long‐term survivors have significantly decreased exercise capacity compared with healthy individuals. Together with their altered body composition, this may predispose them to cardiovascular disease.