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Microbial metabolites and graft versus host disease
Author(s) -
Riwes M.,
Reddy P .
Publication year - 2018
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14443
Subject(s) - immune system , disease , graft versus host disease , medicine , immunology , transplantation , host (biology) , function (biology) , microbiome , biology , microbiology and biotechnology , bioinformatics , ecology , pathology
The health of mammals is a reflection of the diversity and composition of the intestinal microbiota. Alterations in the composition and functions of the intestinal microbiota have been implicated in multiple disease processes. The impact of the microbiota in health and disease is in part a function of the nutrient processing and release of metabolites. Recent studies have uncovered a major role for microbial metabolites in the function of the host immune system by which they influence disease processes such as acute graft versus host disease ( GVHD ), which is the main complication of allogeneic hematopoietic cell transplantation (allo‐ HCT ). The mechanisms of acute GVHD regulation by the complex microbial community and the metabolites released by them are unclear. In this review we summarize major findings of how microbial metabolites interact with the immune system and discuss how these interactions could impact acute GVHD .