American Journal of Transplantation: Volume 17, Number 8, August 2017

On the cover this month: Most humans are infected with the BK polyomavirus, which resides in the urothelium. In immunocompetent individuals, the virus is easily controlled and typically inconsequential. However, in immunosuppressed patients, particularly kidney transplant recipients, immune control of the BK virus is lost, leading to polyomavirus nephropathy (PyVN). Unless recognized early, PyVN can lead to graft loss. In this issue, we present two definitive assessments (Nankivell et al, page 2065, and Drachenberg et al, page 2078) of the evolution of PyVN in kidney transplant recipients. These longitudinal clinical and histological assessments critically outline the course of BK viral reactivation and will be important for the early recognition and study of this unsolved barrier to long‐term graft survival. Also this month, we begin a year‐long series examining cancer in transplant recipients (see editorial by Engels, page 1967), with the first offering in the series, an overview of chemotherapy in transplant patients with malignancy (see Krisl and Doan, page 1974). Cover image by Lauren Halligan, Duke University Department of Surgery .