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A Multicenter Study on Long‐Term Outcomes After Lung Transplantation Comparing Donation After Circulatory Death and Donation After Brain Death
Author(s) -
Suylen V.,
Luijk B.,
Hoek R. A. S.,
Graaf E. A.,
Verschuuren E. A.,
Van De Wauwer C.,
Bekkers J. A.,
Meijer R. C. A.,
Bij W.,
Erasmus M. E.
Publication year - 2017
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14339
Subject(s) - medicine , lung , donation , transplantation , lung transplantation , organ donation , context (archaeology) , surgery , economics , economic growth , paleontology , biology
The implementation of donation after circulatory death category 3 ( DCD 3) was one of the attempts to reduce the gap between supply and demand of donor lungs. In the Netherlands, the total number of potential lung donors was greatly increased by the availability of DCD 3 lungs in addition to the initial standard use of donation after brain death ( DBD ) lungs. From the three lung transplant centers in the Netherlands, 130 DCD 3 recipients were one‐to‐one nearest neighbor propensity score matched with 130 DBD recipients. The primary end points were primary graft dysfunction ( PGD ), posttransplant lung function, freedom from chronic lung allograft dysfunction ( CLAD ), and overall survival. PGD did not differ between the groups. Posttransplant lung function was comparable after bilateral lung transplantation, but seemed worse after DCD 3 single lung transplantation. The incidence of CLAD (p = 0.17) nor the freedom from CLAD (p = 0.36) nor the overall survival (p = 0.40) were significantly different between both groups. The presented multicenter results are derived from a national context where one third of the lung transplantations are performed with DCD 3 lungs. We conclude that the long‐term outcome after lung transplantation with DCD 3 donors is similar to that of DBD donors and that DCD 3 donation can substantially enlarge the donor pool.