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Generating Antigen‐Specific Regulatory T Cells in the Fast Lane
Author(s) -
Ferreira L. M. R.,
Tang Q.
Publication year - 2017
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14202
Subject(s) - foxp3 , il 2 receptor , immune system , immunology , medicine , transplantation , antigen , chimeric antigen receptor , humanized mouse , immune tolerance , immunosuppression , regulatory t cell , human leukocyte antigen , t cell , cancer research , surgery
Human regulatory T cells engineered to express a chimeric antigen receptor targeting HLA‐A2 efficiently suppress alloimmune responses in humanized mouse models of transplantation. See Noyan et al's article on page 917.