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Reactivation of Latent HPV Infections After Renal Transplantation
Author(s) -
Hinten F.,
Hilbrands L. B.,
Meeuwis K. A. P.,
IntHout J.,
Quint W. G. V.,
Hoitsma A. J.,
Massuger L. F. A. G.,
Melchers W. J. G.,
Hullu J. A.
Publication year - 2017
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14181
Subject(s) - medicine , human papillomavirus , sex organ , transplantation , kidney transplantation , genital tract , renal transplant , gynecology , physiology , genetics , biology
Female renal transplant recipients ( RTR s) have an increased risk for developing human papillomavirus ( HPV )–related (pre)malignant lesions of the genital tract. This study aims to assess the genital prevalence of HPV before and after renal transplantation ( RT ). In female patients who were counseled for RT at the Radboud University Medical Center Nijmegen, the Netherlands, gynecological examination was performed at first visit, and 1 and 2 years later. HPV self‐sampling and questionnaires on sexual behavior were performed every 3 months. In 65 patients who underwent RT , the high‐risk human papillomavirus (hr HPV ) prevalence as assessed with the highly sensitive SPF 10 ‐Li PA 25 test increased significantly from 19% before to 31% after RT (p = 0.045). Based upon the clinically validated Cobas 4800 HPV test, the hr HPV prevalence increased from 10% before to 14% after RT (p = 0.31). During follow‐up, no changes in sexual behavior were reported. Thirty‐three patients who did not undergo RT showed a hr HPV prevalence of 21% at study entry and of 27% after 12 months with the sensitive test, and a stable prevalence of 16% with the clinically validated test. The results of this study indicate that activation of latent HPV infections may contribute to the increased risk of HPV ‐related (pre)malignant lesions in female RTR s.